Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...

An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that ...

Further, the research team observed a notable diversity in macrophage types between the two tumor types. The pro-inflammatory M1 macrophages and inflammation-related markers were found to be ...

Researchers identify distinct molecular and immune profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma.

An international team of UK and US scientists discovered that the activity of macrophages -- a type of white blood cell that engulf pathogens and cancer cells -- can be used to predict whether or not ...

The study was published in the journal JCI Insight. Macrophages are immune cells that reside in and protect the lungs and are also recruited to the lungs in high numbers during injury or disease ...

Macrophages have ability to easily penetrate ... Initial applications for therapeutic candidates will be in the treatment of solid tumors. Other potential applications include the disruption ...

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse ...