When Geno Smith stepped to the microphone after another gut-punch of a loss for the Seahawks, this one a 36-24 home defeat to division rival San Francisco, he wasn’t about make any excuses.

Even though a George Kittle touchdown catch put them ahead 23-3, it wasn’t until Kittle caught another third-down scoring strike from Brock Purdy to essentially seal the 49ers’ 36-24 victory. Wait, no,

The 49ers are 3.5-point favorites in the latest Seahawks vs. 49ers odds via SportsLine Consensus, while the over/under for total points scored is 49. The 49ers are -193 money-line favorites, while the Seahawks are +161 underdogs.

The 2024 NFL season resumes on Thursday Night Football as the Seattle Seahawks host the San Francisco 49ers. Find the start time, channel and how to watch.

The Week 6 schedule begins with an NFC West showdown between the San Francisco 49ers and Seattle Seahawks. The 2-3 49ers, who are winless in the division, face the first-place Seahawks, who are 3-2 but have yet to play a game in the NFC West.

Some of the dramatics in the San Francisco 49ers’ Week 6 win over the Seattle Seahawks could have been ratcheted down had the NFL’s replay review system operated properly. In the fourth quarter the Seahawks cut the 49ers’ 20-point lead to 6 with back-to-back touchdowns.

LATEST Oct. 11, 9:30 p.m. Niners head coach Kyle Shanahan offered his thoughts on the NFL's botched replay review that cost San Francisco a turnover in Thursday's 36-24 win over the Seahawks. Shanahan praised 49ers assistant coach Brian Hampton — or as Shanahan called him,

San Francisco 49ers coach Kyle Shanahan made a good challenge. It's not his fault the replay officials missed the call. In the fourth quarter of Thursday night's game, it appeared a punt hit the Seattle Seahawks' punt returner Dee Williams,