Bispecific monoclonal antibody - Wikipedia
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [1] Naturally occurring antibodies typically only target one antigen.
The present and future of bispecific antibodies for cancer therapy
2024年3月6日 · Bispecific antibodies (bsAbs) have gained major interest in the past decade, given their unique and versatile modes of action (MoA). The approval of nine bsAbs for cancer therapy in the past 3...
Bispecific Antibodies: An Area of Research and Clinical Applications
Bispecific antibodies (BsAbs) have two distinct binding domains that can bind to two antigens or two epitopes (an antigen part) of the same antigen simultaneously.
Bispecific and multispecific antibodies in oncology ... - Nature
2024年5月31日 · In this Review, we discuss the role of bispecific antibodies in patients with cancer, including history and development, as well as innovative targeting strategies, clinical applications, and...
Bispecific Antibodies: From Research to Clinical Application
Bispecific antibodies (BsAbs) are antibodies with two binding sites directed at two different antigens or two different epitopes on the same antigen. The clinical therapeutic effects of BsAbs are superior to those of monoclonal antibodies (MoAbs), ...
Bispecific antibodies: design, therapy, perspectives - PMC
Antibodies (Abs) containing two different antigen-binding sites in one molecule are called bispecific. Bispecific Abs (BsAbs) were first described in the 1960s, the first monoclonal BsAbs were generated in the 1980s by hybridoma technology, and the ...
Bispecific antibodies: a mechanistic review of the pipeline
2019年6月7日 · The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively...
Bispecific antibodies: advancing precision oncology - Cell Press
2024年8月29日 · Bispecific antibodies (bsAbs) offer a novel approach to anticancer therapy by targeting different antigens via a range of mechanisms of action. Manipulating bsAb structures allows generation of multiple formats to optimize molecular function for specific clinical contexts.
Bispecific antibodies (bsAbs) are a diverse family of antibodies or antibody constructs that recognize two epitopes or antigens. Most bsAbs are bispecific T-cell-engagers (BiTEs),...
Bispecific antibodies and their applications - PMC - PubMed …
Bispecific antibodies (BsAbs) recognize two different epitopes. This dual specificity opens up a wide range of applications, including redirecting T cells to tumor cells, blocking two different signaling pathways simultaneously, dual targeting of different disease mediators, and delivering payloads to targeted sites.