FoxO signaling pathway - Homo sapiens (human) - GenomeNet
A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors.
FOXO Signaling Pathways as Therapeutic Targets in Cancer
The homeostatic mechanism to manage ROS levels is controlled by signaling pathways that can have both positive (Ras/Ral/ JNK) and negative (PI3K/AKT) effects on FOXO. Growth factors, including insulin, have the capacity to regulate both pathways concurrently.
KEGG PATHWAY: map04068
"Sly as a FOXO": new paths with Forkhead signaling in the brain. STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4 (+) T cells. Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
FOXO Signaling Pathways as Therapeutic Targets in Cancer
2017年7月6日 · Therapeutically targeting the FOXO signaling pathway (s) could lead to the discovery and development of efficacious agents against some cancers, but this requires an enhanced understanding and knowledge of FOXO transcription factors …
FOXO transcription factors: key regulators of cellular ...
FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in cellular metabolism and …
Therapeutic strategies targeting FOXO transcription factors
2020年11月10日 · The PI3K–AKT signalling pathway provides the most important inhibitory input to FOXO activity, while cellular stress signalling activates FOXO proteins 6.
FOXOs: signalling integrators for homeostasis maintenance
2013年1月17日 · At the cellular level, FOXO transcriptional targets are involved in the regulation of cell cycle, apoptosis, oxidative stress resistance and metabolism. FOXOs integrate signals from multiple...