Pathophysiology and pathogenic mechanisms of pulmonary hypertension ...
Schematic diagram of the pulmonary circulation and systemic circulation (A) and distribution of mean pulmonary arterial pressure (mPAP) in normal subjects and patients with idiopathic pulmonary arterial hypertension (IPAH) and chronic …
Pulmonary Hypertension - StatPearls - NCBI Bookshelf
2024年5月1日 · Pulmonary hypertension encompasses a diverse group of conditions characterized by high pulmonary pressures. The World Health Organization classifies pulmonary hypertension into 5 clinical groups based on pathophysiology, hemodynamic characteristics, clinical features, and management (see Table 1.
Mechanisms of disease: pulmonary arterial hypertension
2011年6月21日 · In this Review, we focus on molecular mechanisms involved in the pathogenesis of group 1, pulmonary arterial hypertension (PAH), which includes a variety of diseases that share several...
Pathogenic Mechanisms of Pulmonary Hypertension
2015年1月1日 · Pathogenic features leading to pulmonary arterial hypertension include sustained vasoconstriction, pulmonary vascular remodeling, endothelial dysfunction, in situ thrombosis, and plexiform arteriopathy. Numerous cellular and molecular mechanisms have been demonstrated to contribute to these pathogenic features, involving often complex interactions.
Pathophysiology and pathogenic mechanisms of pulmonary hypertension ...
2023年7月1日 · We focus on reviewing the pathogenic roles of membrane receptors, ion channels, and intracellular Ca 2+ signaling in pulmonary vascular smooth muscle cells in the development and progression of pulmonary hypertension. Keywords: Ca2+ signaling; ion channel; membrane receptor; pulmonary arterial hypertension; pulmonary circulation.
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
2009年6月6日 · Pulmonary arterial hypertension (PAH) is caused by functional and structural changes in the pulmonary vasculature, leading to increased pulmonary vascular resistance. The process of pulmonary vascular remodeling is accompanied by endothelial dysfunction, activation of fibroblasts and smooth muscle cells, crosstalk between cells within the ...
Vascular pathobiology of pulmonary hypertension - ScienceDirect
2023年5月1日 · In this brief review, we cover diverse cell types integral to this vascular pathogenesis - including endothelial cells (ECs), smooth muscle cells (SMCs), pericytes, fibroblasts, immune cells and platelets - and for each cell type, focus on select molecular mechanisms active in that cell type (Figure 1).
Pathogenic Mechanisms of Pulmonary Arterial Hypertension
Endothelial dysfunction, characterized by structural changes and functional impairment of the pulmonary artery, plays an important role in the development and progression of pulmonary arterial hypertension (PAH). Normal synthesis and release of endothelium-derived relaxing factors (EDRFs) is considered a sign of endothelial integrity.
Molecular mechanisms and drug targets for pulmonary hypertension…
Download scientific diagram | Molecular mechanisms and drug targets for pulmonary hypertension. The signaling pathways of endothelin-1 (ET-1), prostacyclin (PGI2), and nitric oxide (NO) are...
Mechanisms of disease: pulmonary arterial hypertension
2011年6月21日 · Once a condition thought to be dominated by increased vasoconstrictor tone and thrombosis, pulmonary arterial hypertension is now seen as a vasculopathy in which structural changes driven by excessive vascular cell growth and inflammation, with recruitment and infiltration of circulating cells, play a major role.