Global Transcription Analysis of Krebs Tricarboxylic Acid Cycle …
To understand the many roles of the Krebs tricarboxylic acid (TCA) cycle in cell function, we used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. mRNA was analyzed from yeast strains harboring defects in each of 15 genes that encode subunits of the eight TCA cycle enzymes.
Global transcription analysis of Krebs tricarboxylic acid ... - PubMed
To understand the many roles of the Krebs tricarboxylic acid (TCA) cycle in cell function, we used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. mRNA was analyzed from yeast strains harboring defects in each of 15 genes that encode subunits of the eight TCA cycle e …
The essential role of mRNA degradation in understanding and engineering ...
2022年1月1日 · The mRNA levels of several glycolytic enzymes (ptsA, encoding the sugar phosphotransferase system component; glk, glucokinase; pgi, phosphoglucose isomerase; tpiA, triose-phosphate isomerase; and eno, enolase) are linked to the expression levels of RNase G and/or RNase III (Lee et al., 2002; Sim et al., 2010) and two mRNAs, aceEF encoding ...
Regulation and function of the mammalian tricarboxylic acid cycle
2023年2月1日 · Regulation of chromatin by tricarboxylic acid (TCA) cycle–associated metabolites. Certain TCA cycle–derived metabolites (left) control the regulation of chromatin and, in turn, gene expression. Histone acetyltransferases (HAT) transfer acetyl groups from acetyl-CoA to histones, thereby altering chromatin accessibility.
Functional expansion of a TCA cycle operon mRNA by a 3′ end …
2019年2月2日 · Here, we present targets of SdhX (RybD), an Hfq-dependent sRNA that is generated by RNase E mediated 3′ processing of the ∼10 000-nt mRNA of the TCA cycle operon sdhCDAB-sucABCD in enteric bacteria. An in silico search predicted ackA mRNA, which encodes acetate kinase, as a
Full article: The impact of RNA binding proteins and the associated ...
In this review, we will discuss the functional roles of RNA binding proteins and their lncRNA partners in TCA cycle, with emphasis placed on the cancer progression.
Gene Expression Profiling of Tricarboxylic Acid Cycle and One …
2021年9月13日 · The tricarboxylic acid (TCA) cycle and carbon metabolism play an important role in tumors. Thus, we aimed to identify new gene signatures from the TCA cycle and carbon metabolism to better predict the survival of COAD. This study performed mRNA expression profiling in large COAD cohorts (n = 417) from The Cancer Genome Atlas (TCGA) database ...
mRNA levels of tricarboxylic acid cycle genes in Streptomyces ...
2022年11月13日 · All TCA cycle-associated genes, including paralog genes, were differentially transcribed in S. coelicolor grown in minimal medium with glucose as carbon source. Some of them, such as succinyl-CoA synthetase and succinate dehydrogenase, have low mRNA levels, which could limit the carbon flux through the TCA cycle.
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of …
In this review, we aimed to provide a comprehensive systematic overview of the molecular mechanisms of each TCA cycle intermediate that may play key roles in regulating cellular immunity in cell stress and discuss its implication for immune activation and suppression.
专家点评Nature子刊｜刘兴国组揭示线粒体TCA酶入核调控多能性的全新模式|线粒体|TCA…
2022年12月7日 · 三羧酸循环(tricarboxylic acid cycle, TCA cycle)作为需氧生物体内最普遍存在的代谢途径，是物质代谢与能量代谢的重要枢纽。线粒体TCA循环酶正常行驶功能是TCA循环维持的关键。